Veterinary medicine knowledge | Best time for veterinary clinical application of doxycycline hydrochloride

Veterinary Drug Doxycycline hydrochloride is also called doxycycline, in animal clinical practice, we often see doxycycline is its hydrochloride; In fact, doxycycline has another application form, which is its monohydrate

Today, we will focus on the most widely used hydrochloride, which is different from aureomycin hydrochloride and oxytetracycline hydrochloride. Doxycycline has high fat solubility, high tissue penetration, strong cell penetration, large distribution volume in vivo, and good antibacterial activity in vivo.

Animal Drug Doxycycline is absorbed quickly after oral administration, and the maximum effect can be exerted after 3 hours, and the effect is maintained for a long time. It is mainly used for upper respiratory tract infection, chronic bronchitis and systemic infection caused by sensitive gram-positive and Gram-negative bacteria. Compared with the metabolism of other tetracycline drugs in the body, doxycycline metabolism in the body is relatively special, it is rarely excreted by the kidney, and most of it is excreted by the small intestine. Therefore, the only way doxycycline can be excreted is through elimination in the stool. Because of this, doxycycline does not accumulate in the body and blood of animals with kidney failure.

Therefore, when the antibacterial treatment of livestock and poultry, especially the treatment of systemic infections, if the animal body is accompanied by kidney failure or kidney insufficiency, other drugs mainly metabolized by the kidney are easy to accumulate in the body because of the decline or dysfunction of the kidney excretion function, and cause further damage to the kidney. At this time, if you choose Bulk drug doxycycline, it is the ideal drug for the treatment of systemic bacterial infections in livestock and poultry. The oral absorption rate of doxycycline is significantly higher than that of other tetracycline drugs. Compared with other food animals, doxycycline has a significantly shorter half-life when taken orally in pigs. After entering the body, doxycycline can accumulate high concentrations in cells, so it has high activity against intracellular pathogens.

1. In the treatment of porcine eperythrozoon, use doxycycline sulfanilamide together for intramural injection. The effect was remarkable. Because eperythrozoon is a pig disease that likes to join in. It usually causes fever and yellow urine in pigs. Redness of the skin. Therefore, in the selection of drugs must also choose Veterinary Apis Drug Shuanghuanglian, lincomycin, and soda powder for comprehensive treatment. Shuanghuanglian clear heat and detoxify, reduce fever. Lincomycin, anti-inflammatory, pain relief, baking soda neutralizes stomach acid, alkalizes urine.

2. in the castration of pigs at the same time, if it is found that there are a lot of purple dots on the belly of the pig, dense. If you castrate a pig, the pig's immune function decreases under stress. They're prone to eperythrozoon. At the same time as castration, doxycycline is used for 5 days. Can effectively prevent the outbreak of eperythrozoonosis.

3.nursing piglets often appear after seven days, yellow with white, white with gray feces. When you use various anti-dysentic antibiotics such as enrofloxacin ampramycin to treat no results, if you choose doxycycline plus sulfanilamide drugs for intramuscular injection, the effect is often unexpected. That's because the piglets may be infected with eperythrozoon, or coccidia.

4.our fat pigs in the dog days, often have a fever rebound, repeatedly. You've been treated with all kinds of antibiotics and sulfanilamide, but if you switch to doxycycline, plus an intramuscular injection of Shuangfen, it won't bounce back.

Why does doxycycline have such a magical effect? That's why eperythrozoon is so prevalent in the summer. Different pigs are infected. Our sows are not immune. Repeated infertility is also a frequent occurrence. The sow showed eperythrozoon, mainly with the clinical symptom of pore bleeding. Piglets have rust like that on their hind legs. Fat pigs showed dense bleeding of the pores of the back, and pale yellow skin appeared in the later stage. Autopsy liver yellow, thin blood and so on.

Now many farmers often like to choose cefplus Astragalus polysaccharide or bupleurum when the pig is sick and has a fever. If it's a mild cold, inflammation, this will help. If you mix with other diseases, then the pig will appear you eat the injection, it will not eat the injection. Not if you choose doxycycline. Because doxycycline for E. coli, mycoplasma pneumonia, eperythrozoon and other pathogens, can be efficient and safe treatment. In addition, misdiagnosed eperythrozoonosis is safer than triazamidine, which is a specific drug for eperythro