In veterinary clinic, Apramycin Sulphate Soluble combined with amoxicillin has synergistic antibacterial effect

Veterinary Drug Apramycin sulfate belongs to aminoglycoside antimicrobials, as well as spectinomycin, kanamycin, gentamicin and neomycin. At present, amprimycin sulfate Soluble Powder with various content specifications is used more and more widely in veterinary treatment

Its qualified properties are: white or white crystalline powder, which is the raw material obtained by biological fermentation and semi-synthesis; It is easily soluble in water, and the aqueous solution is acidic. Its stability in drinking water is very good, and the nephrotoxicity of injection is strong, which is also the reason why it is rarely injected in veterinary clinic of livestock and poultry, and is often given orally in large quantities.

Normally, the intact gastrointestinal tract absorbs very little (generally no more than 3%) of apramycin sulfate when ingested by mouth. However, if the gastrointestinal tract is ulcerated, the mucosa is shed, or there is inflammation, the gastrointestinal tract has a considerable amount of apramycin sulfate absorption. The apramycin sulfate entering the body can be distributed to the heart, liver, spleen, lung, kidney and other organs and some tissues, but the dose of single drug absorbed into the body by oral administration is far from the effective therapeutic dose.

The antibacterial effect of Veterinary Medicine apramycin sulfate is that it first enters the cell of the bacteria, and then it can be combined with the ribosome 30S subunit, thereby inhibiting the synthesis of bacterial proteins and achieving bactericidal effect. The antibacterial effect of Animal Drug amoxicillin is to play a rapid bactericidal effect by irreversibly destroying the bacterial cell wall. It can be seen that apramycin sulfate and amoxicillin sulfate are combined into a veterinary prescription, and amoxicillin is apramycin sulfate: it opens the portal to enter the bacterial cell freely, and this synergistic effect can significantly enhance the antibacterial efficacy of apramycin sulfate and amoxicillin.

Bulk drug Amoxicillin is relatively stable under acidic and weakly alkaline conditions, and its oral bioavailability can reach 90%. Its effect on sensitive bacteria is mainly to kill (many antibiotics only inhibit bacterial growth and reproduction), and the length of effective contact with pathogenic bacteria has a great impact on its effect in veterinary clinical treatment. And amoxicillin oral absorption is better. Such a large number of amoxicillin into the body, and has entered the body, a large number of apramycin sulfate to play a synergistic antibacterial effect, this synergistic antibacterial apramycin sulfate effective therapeutic dose, only need amoxicillin than apramycin sulfate 5:1 amount is enough.

Veterinary Apis Medicine Amoxicillin is relatively stable under acidic and weakly alkaline conditions, and its oral bioavailability can reach 90%. Its effect on sensitive bacteria is mainly to kill (many antibiotics only inhibit bacterial growth and reproduction), and the length of effective contact with pathogenic bacteria has a great impact on its effect in veterinary clinical treatment. And amoxicillin oral absorption is better. Such a large number of amoxicillin into the body, and has entered the body, a large number of apramycin sulfate to play a synergistic antibacterial effect, this synergistic antibacterial apramycin sulphate soluble effective therapeutic dose, only need amoxicillin than apramycin sulphate soluble 5:1 amount is enough.