Veterinary Drug products, Veterinary Medicine raw powder/Comparison and difference analysis between different Veterinary Drug

As we all know, the use of antibiotic drugs is required after use, in a certain period of time to kill the bacteria, if the drug effect is not up to expectations, not killed bacteria will develop resistance, once the bacteria develop resistance to this kind of drug, the effect will become worse and worse; In addition, the compound can not meet the corresponding quality standards. Simple and extensive compounds may produce or carry corresponding uncontrollable impurities or harmful substances, and the stability of the drug is uncertain, and it is likely that the drug will degrade after a few hours. Drug stability, bioavailability and so on can not be effectively controlled, resulting in low drug utilization, increased toxicity, side effects. The use of such drugs to animals, not only can not achieve the desired effect, the impurities produced on the animal is a kind of harm. In particular, in many cases, the ingredients of large compounds are not clear, and drugs with unknown ingredients in use are mixed and react with each other, resulting in toxicity, which leads to problems in product testing and affects food safety. The use of raw materials and "large compounds" is neither economical nor safe, and clinical veterinarians need to diagnose and analyze the pathogens, select the preparation products produced by scientific preparation technology, and treat animal diseases by single drug or combined drug according to the needs of the disease, so as to achieve the purpose of effective, safe and economic drug use. Therefore, when purchasing a good or efficient national standard drug preparation, it is mainly investigated for its drug solubility, dissolution, stability, bioavailability, or bioequivalence with the original drug. Here is a brief explanation of these indicators.

The first is purity

According to the different ideas, values and pursuits of each enterprise, ordinary drug manufacturers are unwilling or unable to invest in such high research and development, although the desire and publicity are high-tech and efficient drugs; In fact, it is to buy raw materials and auxiliary materials, rely on modern pharmaceutical equipment, and carry out veterinary drugs produced by "incoming processing". In today's Veterinary Drug production groups, almost 90% or more are such enterprises. The magic weapon for such enterprises to compete in the market is: return goods, lower prices, travel, send gifts, high return points, etc., and make a big deal about non-core drugs. Another type of enterprise is the innovative veterinary drug manufacturers. This kind of enterprise has a clear, sustainable, can support the concept of medicine and values, they through the development and production of efficient, convenient and economical new veterinary drugs, to provide users with unique products and services. By improving the purity of raw materials, auxiliary materials, additives, etc., to improve the effectiveness and safety of the preparation; Through the development and application of solid dispersion preparation, coated pellet preparation, nano milk preparation and other high-tech preparations, to provide users with higher use value of high-quality standard general drugs.

The second is stability

From administration to effect, stable drugs need to go through a series of processes such as dissolution, dissolution, absorption into the blood and distribution to the site of action. Degradation and destruction of the active ingredients in any process of the preparation will lead to reduced therapeutic effect, or even complete failure. Therefore, the stability of the active ingredient in the preparation is a necessary condition to ensure the clinical efficacy of the drug, and the active ingredient must remain stable in water for 5 to 24 hours.

The third is solubility

Water administration is the most convenient way for livestock and poultry at present and a good water-soluble preparation must first have good water solubility. Because clinical administration is mostly concentrated, the solubility of the drug in water should reach more than 3-5 times the clinical recommended dose.

The fourth is dissolution

The drug active ingredients in the preparation must be transformed into a molecular state when they enter the body, so that they can be absorbed by the gastrointestinal tract into the blood circulation, and then reach the lesion site to have an effect. This process is the dissolution of the drug, and the speed and degree of dissolution of the active ingredient is the dissolution degree of the preparation. Dissolution degree is an effective means to evaluate the quality and technological level of the preparation, and is also an effective standard to evaluate the bioavailability of the active ingredients of the preparation.

The fifth is equivalen

That is, bioequivalence, is to compare the degree and speed of absorption of active ingredients of the same or different dosage forms of the same drug under the same test conditions. It is a standard to judge the bioavailability and clinical therapeutic effect of drug preparations. The method is to determine the concentration of the drug in plasma at different times after drug administration. If the area under the curve at the time of drug administration is 80%-125% of the original drug, it can be determined that the two preparations are bioequivalent and can be completely replaced.