The combination effect of Veterinary Medicine amoxicillin and Veterinary Drug colistin is better

Animal Drug Amoxicillin is a semi-synthetic penicillin antibiotics, a breeding period fungicide (class I), is a penicillin with amino side chain, but the effect of penicillin is several times stronger, can hinder the synthesis of cell wall mucopeptide, the cell wall defect of the bacteria, the cell body expansion and lysis and death, mainly used for gram-positive bacteria and some negative bacteria infection disease.

Veterinary Apis Drug Colistin sulfate is an alkaline polypeptide antibiotic, which mainly acts on the cell membrane of bacteria, prevents the infection of sensitive bacteria and promotes the growth of livestock and poultry, and belongs to the quiescence phase fungicide (Class II). At the same time, Pharmaceutical Raw Materials colistin sulfate can also affect the function of nucleoplasm and ribosome, so that bacteria are not easy to develop resistance to it, and there is no cross-resistance with other antibiotics, which is the most obvious biological Veterinary Drug used to prevent and treat intestinal diseases caused by gram-negative bacteria in the world.

1. From the antibacterial mechanism analysis, can be used together. Both drugs are commonly used to prevent and treat intestinal bacterial infections in pigs and chickens. They belong to breeding period fungicides (Class I) and resting period fungicides (Class II) respectively, which have destructive effects on bacterial cells and can cooperate with each other to significantly improve their antibacterial effect.

2. From the antibacterial effect and dose analysis, it can be used together. The combination of two drugs not only makes good use of the antibacterial action of single drug, but also gives full play to the synergistic antibacterial advantage of the combination of two drugs, which can expand the antibacterial spectrum, effectively prevent and control the mixed infection or secondary infection of livestock and poultry, and reduce the dose and the generation of drug-resistant strains.

3. From the chemical structure analysis of the two, they can be used together.

(1) The combination of medication is conducive to the stability of colistin sulfate molecular structure. When the two coexist in the system at the same time, the -NH2 of colistin sulfate will bind with the -COOH of amoxicillin, thus protecting colistin sulfate molecules and preventing the -NH2 part from being easily oxidized; After the combination enters the gastric fluid, -NH2 is re-isolated or formed into the form of -NH3+ to exert the antifungal effect of its molecular prototype. If used alone, the -NH2 portion of colistin sulfate molecules is easily oxidized, causing the molecules to lose their potency.

(2) The combination of amoxicillin is conducive to the stability of the molecular structure of amoxicillin: when amoxicillin interacts with acids, bases, hydroxylamines or certain metal ions (copper ions, lead ions, mercury ions or silver ions), molecular rearrangement or hydrolysis is easy to occur, and the efficacy is lost. The colistin sulfate molecule is a polyamine structure and a negative electron molecule, which may chelate the above metal ions, so as to reduce or eliminate the disadvantages of chelating metal ions with amoxicillin alone, so that amoxicillin can maximize its efficacy.

Therefore, amoxicillin and colistin can not only be compatible, but also can play 1+1 Effects of 2